Biomimetic Transamination of ^|^alpha;-Keto Esters

Organocatalytic synthesis of optically active β-branched α-amino esters via asymmetric biomimetic transamination.

This paper describes an efficient asymmetric biomimetic transamination of α-keto esters with a quinine-derived chiral base as the catalyst, giving a variety of β-branched α-amino esters in 50-96% yield and 87-95% ee.

Synthesis of alpha-keto esters by the rhodium-catalysed reaction of cyanoformate with arylboronic acids.

An arylrhodium(I) species selectively reacts with the cyano group of ethyl cyanoformate to afford the corresponding alpha-keto ester in good yield.

N-terminal protein modification through a biomimetic transamination reaction.

Highly Enantioselective Hydrogenation of a-Keto Esters Catalyzed by Ru-Tunephos Complexes Highly Enantioselective Hydrogenation of a-Keto Esters

SYNLETT 2006, No. 8, pp 1169–117215.05.2006 Advanced online publication: 10.03.2006 DOI: 10.1055/s-2006-932461; Art ID: W30605ST © Georg Thieme Verlag Stuttgart · New York Abstract: Various enantiomerically pure a-hydroxy esters were synthesized by asymmetric hydrogenation of a-keto esters catalyzed by Ru-Cn-Tunephos complex. Up to 97.1% ee has been achieved for both a-aryl and a-alkyl substitu...

An efficient synthesis of aryl a-keto esters

A new one-pot approach for the synthesis of aryl a-keto ester based on the diazo transfer and oxidation of diazo group is developed. 2005 Elsevier Ltd. All rights reserved. 1 3 Ar OMe O [O] Ar OMe O O Ar OMe N2 [O] Base ArSO2N3 a-Keto acids and esters have been important compounds as natural products and as the building blocks in organic synthesis. Over the past decades, various methods have be...